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Phase 2 safety profile is consistent with the GLP-1 receptor agonist class, dominated by dose-dependent gastrointestinal adverse events that concentrate in the first one to two weeks of each escalation step

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It was shown that the expression of FPN was significantly reduced in CCA (89)

"Microdosing" is a non-clinical term used to describe staying at a dose lower than the standard starting point or refusing to escalate the dose as scheduled