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This may be particularly important if drugs promoting OPC differentiation lead to eventual depletion of the progenitor pool, and considering that aged OPCs have decreased capacity to mature and remyelinate, and are less responsive to pro-remyelinating drugs 101
(9) Elena M Khvatova, Victor N Samartzev, Pavel P Zagoskin, Igor A Prudchenko, and Inessa I Mikhaleva (2003) Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia Peptides, 2003 Feb, Volume 24 (Issue 2), Pages 307-11
Table 3 Association of carnitine palmitoyltransferase 2 ( CPT2 ) genotypes with complete response
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